This is not an entire list of achievable side effects. For those who observe other Unwanted effects not mentioned higher than, contact your medical professional or pharmacist.
Carcinogenicity studies ended up done with promethazine hydrochloride. Two-12 months scientific tests in F344/N rats and B6C3F1 mice were performed to evaluate the carcinogenic opportunity of promethazine hydrochloride. No proof of tumorigenicity was observed in male and woman rats at promethazine hydrochloride oral doses approximately 33 mg/kg/working day for five days/7 days (around similar to ten occasions the MRHD on the mg/m2 basis).
Applying this medication with any of the next medicines is usually not suggested, but can be needed sometimes. If both of those medicines are prescribed together, your medical professional may possibly alter the dose or how frequently you utilize a person or the two with the medicines.
To reduce the potential risk of dizziness and lightheadedness, get up slowly but surely when growing from the sitting down or lying posture.
Sedating medicine may possibly trigger confusion and more than-sedation within the elderly; elderly individuals generally need to be started out on minimal doses of promethazine with codeine syrup and observed closely.
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Pregnancy Checks: Diagnostic pregnancy tests determined by immunological reactions concerning HCG and anti-HCG might end in Untrue-detrimental or false-constructive interpretations.
Codeine was not mutagenic from the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Will not flush prescription drugs down the bathroom or pour them into a drain unless instructed to take action. Effectively discard this solution when it is expired or now not wanted. Talk to your pharmacist or neighborhood squander disposal corporation.
Promethazine hydrochloride really should not be Utilized in pediatric patients fewer than 2 years of age due to likely for fatal respiratory melancholy. Postmarketing instances of respiratory despair, like fatalities, happen to be claimed with utilization of promethazine in pediatric people below two several years of age. A wide range of body weight-primarily based doses of promethazine have resulted in respiratory melancholy in these people.
Tend not to flush down a rest more info room or pour down a drain Unless of course you might be instructed to do so. Check with your pharmacist if you have questions on The easiest method to throw out medication. There might be drug just take-back programs in your neighborhood. Customer Information Use and Disclaimer
Promethazine is effectively absorbed in the gastrointestinal tract. Scientific outcomes are evident within twenty minutes soon after oral administration and generally previous 4 to 6 hours, Whilst they may persist providing twelve several hours.
Codeine and its salts are well absorbed subsequent the two oral and parenteral administration. Codeine is about ⅔ as successful orally as parenterally. Codeine is metabolized mostly while in the liver by enzymes on the endoplasmic reticulum, the place it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Convey to your medical doctor When your cough would not get better in 5 days. Also, inform your medical professional If the ailment receives even worse, or if you have a headache that does not disappear, fever, or rash. These may be signs and symptoms of a serious healthcare difficulty and should be checked by a doctor.